Model 1800 Microelectrode AC Amplifier The Model 1800 AC Microelectrode Amplifier is a two-channel, differential amplifier configured for use with headstage probes. The instrument is intended for extracellular recording and/or stimulating in conjunction with high impedance metal microelectrodes. Ideal for single-cell spike recordings, it can also be used in a number of research or teaching applications requiring extracellular neurophysiological recording from excitable tissue such as nerve, muscle (EMG), EEG, EKG, and ERG recordings. Each channel of the Model 1800 contains a high-gain, low-noise differential amplifier stage followed by low-frequency, high-frequency, and notch filters. Three operating modes are available to accomodate recording, stimulating, and verification of electrode x10 Headstage Probe impedance. Multiple gain settings and simultaneous current measurements during stimulation are provided. An internally calibrated current source allows in situ verification Two amplifiers in one instrument of electrode impedance. Can record from or stimulate through The Model 1800 Headstage includes a mounting rod and bracket for a standard electrodes without changing connections micromanipulator and a complete set of miniature electrode cables. Fixed Gain: x100, x1000, or x10,000 Common applications for the Model 1800 Microelectrode AC Amplifier include, but are Low noise not limited to: Single Cell Action Potentials Multiple-Unit Recordings Notch filter for power line frequency EEG / EMG / EKG / ERG recordings Long-term Potentiation Evoked Potentials Waveform Sorting In situ electrode impedance measurement Current monitor during stimulation The Model 1800 Microelectrode AC Amplifier is designed for research grade recording Includes rack mount hardware quality, with a straightforward interface that also makes it ideal for teaching applications. 3-year warranty Model 1800 Microelectrode AC Amplifier The Model 1800 Microelectrode AC Amplifier was designed to record from two different electrodes simultaneously. Application Recently, many users have requested the ability to record both spikes and EEG/Evoked potentials from the same Notes: 1) recording electrode simultaneously. A-M Systems can modify the Model 1800 circuitry to accomplish this task. The output EEG and spikes from the Channel 1 headstage is routed internally to the input to the Channel 2 circuitry. The same signal can then simultaneously be filtered at different settings by the Channel 1 and 2 filter stages. Contact A-M Systems, or your distributor, for more information. The Model 1800 Microelectrode AC Amplifier can both record from the electrode, or pass externally generated 2) Automated control of instrument MODE current to the electrode, without requiring the user to change the connections at the headstage. To do so, the user must set the MODE switch on the front panel to REC or STIM. A-M Systems can modify the 1800 to allow a computer or other instrument to send a TTL level signal to control the 1800’s mode, allowing for a faster and more controlled switching between recording and stimulation modes. Gain* x100, x1000, x10000 Specifications High Pass Filter* 0.1, 1.0, 10, 100, and 300 Hz; -40 dB / decade Low Pass Filter* 500, 1000, 5000, 10000, and 20000 Hz; -40 dB / decade Notch Filter >-25dB at 50 or -30dB at 60 Hz. Noise 1.0 microvolt p-p typical (10 Hz to 10,000 Hz) Common Mode Rejection > 80 dB Input Impedance >100,000 megohms Low Input Bias Current (± 3 pA typical) Other Features Can pass stimulation current direct to electrodes Built-In current monitor during stimulation In-situ electrode impedance measurement (up to 40 megohms) * Can customize these values for an additional fee. Contact A-M Systems or your distributor for information Kwon, JT and Choi, JS. (2009) Cornering the fear engram: Long-term synaptic changes in the lateral nucleus of the References Amygdala after fear conditioning. J Neuroscience 29(31): 9700-9703 Aflalo, T and Graziano, MSA (2006) Partial tuning of motor cortex neurons to final posture in a free-moving paradigm. PNAS 103(8):2909-2914 Cator et al. (2009) Harmonic Convergence in the Love Songs of the Dengue Vector Mosquito. Science 323 (5917):1077-1079 # Ordering For use on 220 V / 50 Hz power systems: Product 700005 Country-specific power cords are not supplied. # For use on 110 V / 60 Hz power systems: Product 700000 Information # Two Product 700500 Headstage probes must be purchased at time of ordering for proper operation of the instrument. All units include a product manual and rack mounts. Toll-free: 800-426-1306 (USA) Distributed By: A-M Systems Phone: 360-683-8300 131 Business Park Loop FAX: 360-683-3525 PO Box 850 E-Mail: sales@a-msystems.com Carlsborg, WA 98324 USA Website: www.a-msystems.com